Disaccharidases - small bowel mucosa
Small bowel biopsy: at least 5 mg fresh tissue transported in a container on melting ice.
Spectrophotometry on tissue extract with assay of lactase, sucrase, maltase, isomaltase, as appropriate.
|Reference Interval:|| |
Depends on laboratory.
Investigation of patients with diarrhoea and/or colic in whom sugar intolerance is suspected; investigation of those with small bowel malabsorption.
All brush border enzymes are reduced in subtotal villous atrophy; lactase is very low in lactose intolerance; sucrase and isomaltase are very low in sucrose intolerance.
Lebenthal E, Lee PC. J Pediatr. 1980; 97: 389-393.