Moderate, severe or end-stage reduction in GFR persisting for more than 3 months indicates Chronic Kidney Disease. Rapid reductions may indicate acute renal failure.
eGFR is accurate to approx +/- 30%
Reduced accuracy in extremes of body composition, eg extreme muscularity, obesity, emaciation, paraplegia etc.
While likely to be appropriate, eGFR is not validated in all racial groups and should be interpreted with caution.
Not suitable for use in children, pregnancy, dialysis.
If result is uncertain, formal GFR measurement or Creatinine clearance may be indicated.