Factor XIII


4.5 mL blood added to 0.5 mL citrate.

Method:Clot solubility test.
Reference Interval:

Qualitative test which detects major deficiencies of Factor XIII.


Investigation of patients with a personal and/or family history suggestive of an inherited bleeding disorder.

Factor XIII (fibrin stabilising factor) deficiency is rare.


In the presence of factor XIII, fibrin is stabilised by transglutaminase-mediated peptide bonds and the clot is insoluble in eg, strong urea.

In patients with factor XIII deficiency, cross-linking of fibrin is deficient resulting in reduced structural integrity of the clot. The sensitivity of this test is low - consult pathologist.


Bain et al. Dacie and Lewis Practical Haematology.11th ed. 2012.

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