Assessment of lymphoid cell subsets especially CD4 numbers in patients with HIV infection;
classification of acute and chronic leukaemias and lymphomas;
occasionally required to distinguish reactive and neoplastic lymphocytosis;
detection of minimal residual disease / after fetomaternal haemorrhage add diagnosis of hereditary spherocytosis.
May also be used to count reticulocytes;
to detect platelet antibodies, to detect cell sub-populations (eg, red cell, leucocyte and platelet sub-populations in PNH), fetal red cells after fetomaternal haemorrhage;
to identify HLA-B27 phenotype;
to determine DNA ploidy and cell cycle characteristics; and
to enumerate stem cell numbers prior to peripheral blood progenitor cell collection for transplantation.