Follicle stimulating hormone
5 mL blood in lithium heparin tube.
|Reference Interval:|| |
Method dependent, and related to menstrual cycle in females.
Female: 1.0-8.0 U/L
Post-menopausal female: > 18.0 U/L
Adult male: 1.0-5.0 U/L (age related).
Investigation of gonadal hypofunction, suspected pituitary tumour.
Levels are increased when pituitary secretion occurs in the absence of feedback inhibition by gonadal androgens or oestrogens (primary gonadal hypofunction, post-menopausal state, castration).
Increased levels may also be seen with pituitary gonadotroph tumours, although some tumours secrete only the α subunit.
Levels are decreased if ovarian or testicular failure is due to pituitary or hypothalamic disease.
AMH is a more reliable marker of ovarian reserve.
Thorner MO et al. In: Wilson JD and Foster DW eds. Williams Textbook of Endocrinology. 8th ed 1992. WB Saunders.