The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Hepatitis C antibody, Hep C antibody, HCV antibody, HCV
5-10 mL blood in plain tube.
Immunoassay ± immunoblot.
Detection of HCV as a cause of acute hepatitis, chronic hepatitis, cirrhosis, hepatocellular carcinoma;
testing for infectivity in blood, semen or tissue transplant donors, after needle stick injury;
testing patients who have received blood or blood products eg renal dialysis patients;
investigation of patients with mixed essential cryoglobulinaemia.
Hepatitis C viral RNA provides a clearer indication of prognosis and infectivity and can be used to monitor treatment (see Hepatitis C nucleic acid).
A positive initial test for anti-HCV antibodies can only be considered as a definite positive result if it is confirmed by a second immunoassay using different antigens or an immunoblot.
The test usually becomes positive 4 to 6 weeks after infection, but it may take up to 6 months for seroconversion to occur.
The significance of indeterminate results can only be determined by re-testing after 3 to 6 months.
Alternatively, Hepatitis C virus (HCV) RNA may be useful for diagnosis or assessment of infectivity in this circumstance.
A positive HCV antibody test indicates previous or ongoing HCV infection.
Rosenberg PM. Clin Infect Dis. 2001; 33: 1728-1732.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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