The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Herpes simplex antibody, HSV antibody, HSV
5-10 mL blood or 2 mL CSF in plain tube.
Acute and convalescent (10-14 days) samples.
Of limited usefulness in the diagnosis of primary oral or genital herpes.
If testing is indicated clinically, viral antigen testing is the preferred test, with NAA being the most sensitive method.
See Virus detection.
A seroconversion from negative to positive or a four-fold rise in titre between acute and convalescent samples supports the diagnosis of primary herpes infection.
Antigenic cross reactivity occurs between HSV-1 and HSV-2.
Recurrent infections may not stimulate a significant increase in antibody titre.
Viral culture and direct antigen detection performed on vesicle fluid or material scraped from the base of a vesicle/ulcer are more rapid and reliable methods to diagnose both primary and recurrent HSV-1 or HSV-2 infection.
Serum antibody testing has not been of value in herpes encephalitis, although the presence of IgM antibodies in CSF may support a presumptive diagnosis.
PCR is the preferred test for the diagnosis of HSV encephalitis.
Ashley RL and Wald A. Clin Microbiol Rev. 1999; 12: 1-8.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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