The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Intrinsic factor antibody, IFA
5 mL blood in plain tube.
As recent vitamin B12 administration is associated with a high rate of false positive results the sample must be collected prior to commencing therapy or at least one week after vitamin B12 administration.
Diagnosis of pernicious anaemia.
High specificity for pernicious anaemia. A positive result is sufficient to establish the diagnosis.
Sensitivity is low thus a negative result does not exclude the diagnosis of pernicious anaemia.
Type 1 (blocking) antibody prevents the attachment of vitamin B12 to intrinsic factor: present in 50-60% of patients with pernicious anaemia.
Type 2 (precipitating) antibody prevents attachment of the vitamin B12-intrinsic factor complex to ileal receptors: present in 30% of patients with pernicious anaemia, and only in those who also have Type 1 antibodies.
Immunoassay kits which rely on blocking function of antibodies are usually less sensitive.
Oh R et al. Am Fam Physician. 2003; 67(5): 993-994.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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