Lymphocyte proliferative response
30 mL blood in preservative-free heparin.
The proliferative response to specific antigen or mitogen (eg, phytohaemagglutinin [PHA], concanavalin A, pokeweed mitogen) is demonstrated by uptake of tritiated thymidine or expression of differentiation markers. Use of CFSU.
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Assessment of cell mediated immune competence.
May be of use in assessment of histocompatibility differences in organ transplantation.
Rarely indicated as a diagnostic test outside tranplantation area.
Impaired T lymphocyte proliferative response to mitogen or to HLA-incompatible stimulator cells indicates depressed cell mediated immunity.
Fletcher M et al. In: Rosen NR et al eds. Manual of Clinical Laboratory Immunology. 4th ed. 1997. ASM Press.