The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: MCV, Erythrocyte mean corpuscular volume
5 mL blood in EDTA tube.
Part of Full blood count; measured by most automated and semi-automated instruments (some provide red cell size distribution curves).
Arithmetically, MCV is Haematocrit (Hct or PCV) divided by RCC (red cell count).
Refer to laboratory – guide only provided below:
Term infant cord blood (mean): 106 fL
3 months (mean): 95 fL
1 year: 70-86 fL
3-6 years: 73-89 fL
10-12 years: 77-91 fL
Adult: 80-100 fL.
Guide to investigation of Anaemia; Blood film should also be requested.
Macrocytosis (high MCV) is found in megaloblastic, aplastic, dyserythropoietic and sideroblastic anaemias; Myelodysplastic syndromes, myeloma; Liver disease, alcohol excess; chronic hypoxic lung disease; myxoedema; following renal transplant; cytotoxic drug therapy particularly hydroxyurea, therapy with Zidovudine (AZT); and some rare metabolic disorders.
A reticulocytosis may be associated with a mild increase in MCV.
Microcytosis (low MCV) is found in iron deficiency anaemia, some cases of anaemia of chronic disease, haemoglobinopathies (especially the Thalassaemias), lead toxicity, congenital sideroblastosis and rare red cell enzyme deficiencies.
See also Red cell distribution width.
Bain et al. Dacie and Lewis Practical Haematology. 11th Ed. 2012.
Bain BJ. Blood cells: a practical guide. 4th Ed. 2007. Oxford: Blackwell Publishing.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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