The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
Donate online now using the button below. RCPA Foundation thanks you for your generous support. All funds raised will be allocated to the RCPA Foundation Pathology Education Outreach Fellowship.
Events and Sponsorship Manager
Ph: +61 2 8356 5806
Fax: +61 2 8356 5828
Events and Grants Coordinator
Ph: +61 2 8356 5852
Fax: +61 2 8356 5828
Tissue may be collected by needle biopsy or open biopsy (recommended).
While some texts advocate clamping of the specimen to prevent contraction, it is generally recommended that the fresh specimen be placed on gauze and kept cool during rapid transportation to the laboratory.
The specimen should not be placed in isotonic saline.
In the laboratory the specimen will be orientated and portions sampled for light microscopy, electron microscopy, immunohistochemistry and histochemistry.
Laboratory staff should be contacted for advice regarding the handling of muscle biopsy.
Some myopathies may require chemical pathology, molecular genetics and histochemical studies. These can be done only in centres with the appropriate facilities and after consultation.
Fresh tissue: frozen section, biochemical and molecular genetic studies.
Fixed tissue: light microscopy, immunohistochemistry, electron microscopy (special fixative).
Investigation of congenital inflammatory and metabolic myopathies (including glycogen storage disease), and neurogenic muscular disease.
Categorisation of muscle disease including muscular dystrophies, polymyositis and metabolic myopathies.
Identification of denervation atrophy.
Dubowitz V. Muscle biopsy a practical approach. 4th Ed. 2013. Saunders.
Page last updated:
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
Copyright © 2020 RCPA. All rights reserved.