NT-proBNP < 300 ng/L Congestive heart failure (CHF) unlikely.
Consistent with the diagnosis of CHF
Age < 50 years NT-proBNP > 450 ng/L
Age 50-70 years NT-proBNP > 900 ng/L
Age > 70 years NT-proBNP > 1800 ng/L
NT-proBNP has a longer half-life than BNP. Circulating levels are similar to BNP in normal individuals, but are significantly more elevated by left ventricular dysfunction than BNP.
NT-proBNP levels may be elevated by factors other than CHF, such as acute coronary syndrome, pulmonary embolism, shock, atrial arrhythmia, severe pneumonia and renal disease.
NT-proBNP levels are higher in women than men, increase with age and have an inverse relationship with BMI (lower in obesity).