The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Neutrophil antibody
Rarely used and only performed in specialised laboratories.
10 mL blood in EDTA for 'direct' tests of neutrophil-bound antibody and 10 mL in plain tube for 'indirect' tests of antibody in serum
Direct and indirect Immunofluorescence, Flow cytometry, agglutination.
Investigation of neutropenia, when immune-mediated (including drug-induced) neutropenia is suspected. Investigation of suspected cases of neonatal alloimmune neutropenia (NAIN). Investigation of suspected cases of transfusion-related acute lung injury (TRALI).
A positive result is seen in immune neutropenia and drug-induced neutropenia eg, secondary to penicillins, cephalosporins, vancomycin.
Antibodies to Human Neutrophil Antigens (HNAs) are seen in cases of NAIN, and TRALI. Results are usually correlated with HNA genotyping results – specialised testing and consultation with pathologist required.
Bain et al. Dacie and Lewis Practical Haematology. 11th Ed. 2012.
Muschter S et al. Curr Opin Hematol. 2011; 18, 452-460.
Clay ME et al. Immunohematology. 2010; 26(10, 11-22.
Stroncek D. Vox Sang. 2004; 87 (suppl 1), s91-s94.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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