The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
Donate online now using the button below. RCPA Foundation thanks you for your generous support. All funds raised will be allocated to the RCPA Foundation Pathology Education Outreach Fellowship.
Events and Sponsorship Manager
Ph: +61 2 8356 5806
Fax: +61 2 8356 5828
Events and Grants Coordinator
Ph: +61 2 8356 5852
Fax: +61 2 8356 5828
5 mL blood in plain tube.
Depends on gestational age and whether total (free and conjugated) or free oestriol is measured.
Levels should increase progressively during pregnancy.
Although it has been used for monitoring placental function and fetal status in high risk pregnancies from 26 weeks gestation, the test is now considered to be of little value and is rarely used.
Unconjugated oestriol is, however, one of the components of the 'triple test' used for assessment of Down syndrome risk, see Down syndrome antenatal risk test.
Urine oestriol can be measured, but is also unreliable.
Trends in levels are more reliable than single values.
Decreasing levels suggest placental insufficiency and/or fetal problems.
Low levels are found in anencephaly, congenital adrenal hyperplasia, placental sulphatase deficiency (X-linked ichthyosis), adrenal hypoplasia and steroid therapy.
Impaired maternal liver function decreases clearance of oestriol from plasma and may make interpretation impossible.
Beischer N et al. Aust NZ J Obstet Gynaecol 1995; 35: 151-159.
Page last updated:
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
Copyright © 2019 RCPA. All rights reserved.