The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
Donate online now using the button below. RCPA Foundation thanks you for your generous support. All funds raised will be allocated to the RCPA Foundation Pathology Education Outreach Fellowship.
Events and Sponsorship Manager
Ph: +61 2 8356 5806
Fax: +61 2 8356 5828
Events and Grants Coordinator
Ph: +61 2 8356 5852
Fax: +61 2 8356 5828
Keywords: Acetaminophen level
5 mL blood in plain tube collected, ideally 4 h after ingestion of the paracetamol.
A second specimen collected at least 2 h later can be used to measure paracetamol half-life.
Spectrophotometry, chromatography, or immunoassay.
Toxic range: > 1,300 µmol/L (195 mg/L) 4h after ingestion of paracetamol.
< 4 h: low probability of liver damage
> 12 h: hepatic coma likely.
Assessment of toxic overdose.
See Figure 2.
Toxicity is more likely and occurs at lower plasma levels in patients with pre-existing liver disease.
Calculation of half-life (from two specimens) is also a useful guide to hepatotoxicity as prolongation of half-life is a good predictor of the risk of development of acute hepatocellular damage.
Dargan PI and Jones AL. Trends Pharmacol Sci 2003; 24(4): 154-157.
Page last updated:
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
Copyright © 2019 RCPA. All rights reserved.