The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
Donate online now using the button below. RCPA Foundation thanks you for your generous support. All funds raised will be allocated to the RCPA Foundation Pathology Education Outreach Fellowship.
Events and Sponsorship Manager
Ph: +61 2 8356 5806
Fax: +61 2 8356 5828
Events and Grants Coordinator
Ph: +61 2 8356 5852
Fax: +61 2 8356 5828
Keywords: Platelet function studies, PLT function studies
Citrated blood; generally requires prior arrangement with laboratory.
Ideally the patient should not have taken aspirin or other NSAID or drug/compound affecting platelet function in the week prior to testing.
Platelet-rich plasma stirred at 37°C with continuous recording of light transmission. Aggregating agent (agonist) added; aggregation results in decreasing optical density.
The platelet release reaction is assessed by the presence of secondary aggregation with ADP, adrenaline; aggregation with collagen, arachidonate.
The release reaction can be measured by prior incubation of platelet-rich plasma with labelled serotonin, and measurement of radioactivity in supernatant plasma following aggregation or using other reagents.
Platelet function is predictably abnormal after ingestion of aspirin and other NSAIDs and in patients with uraemia.
Platelet function may be abnormal in patients with Myeloproliferative neoplasms, Myelodysplastic syndromes and in Paraproteinaemia.
Pattern of aggregation and presence or absence of 'primary' or 'secondary' waves help to define various platelet functional disorders.
Bain et al. Dacie and Lewis Practical Haematology. 11th Ed. 2012.
Hutton R.A. et al. J Clin Pathol. 1989; 42: 858-864.
Page last updated:
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
Copyright © 2019 RCPA. All rights reserved.