The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Random urine, protected from light and refrigerated if immediate analysis is not possible.
Porphyrins (total): spectrophotometry, fluorometry.
Uroporphyrin, coproporphyrin: HPLC.
Porphyrins (total): < 250 nmol/L
Uroporphyrin: < 40 nmol/L
Coproporphyrin: < 240 nmol/L
The test is only reliable if the patient is symptomatic when the specimen is collected.
Diagnosis of acute neurological porphyrias (acute intermittent porphyria, porphyria variegata, hereditary coproporphyria) or porphyria cutanea tarda.
It may be used to diagnose lead poisoning but blood lead is the recommended test.
Increased coproporphyrin occurs in porphyria variegata, hereditary coproporphyria, and the porphyrinurias due to lead poisoning and cholestasis.
Increased uroporphyrin occurs in porphyria cutanea tarda, in which increased hepta-, hexa-, and penta-carboxylporphyrins are also found.
Uroporphyrin is also increased in acute intermittent porphyria due to chemical conversion from porphobilinogen in urine.
Lecha M et al. Dermatol Ther. 2003; 16(1): 65-72.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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