The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Q fever antibody, Q fever serology, Coxiella burnetti antibody
Specimen: 5-10 mL blood in plain tube at onset and 2-3 weeks after onset of illness.
The request form should indicate the purpose of the testing (eg, pre-vaccination screening, possible acute infection or chronic Q fever infection, since different tests are used for each of these).
CFT, IFA, EIA.
Diagnosis of suspected Q fever, atypical pneumonia, hepatitis of unknown cause or blood culture-negative endocarditis.
Occupational health screening of abattoir and livestock workers at commencement of employment or after vaccination.
If chronic Q fever is suspected (eg, endocarditis) antibodies to phase I antigen should be specifically requested.
Infection with Coxiella burnetii stimulates antibodies to both phase I and phase II antigens.
In acute Q fever, antibodies to phase II antigen are detectable 1-2 weeks after onset of the illness and peak between 4 and 12 weeks.
Recent infection is confirmed by a four fold rise in titre or a positive IgM test. A single CFT titre of > 8 for antibodies to phase II antigen indicates past infection.
Antibodies to phase I antigen are only present in significant titre in chronic Q fever (eg, endocarditis or granulomatous liver disease).
Maurin M and Raoult D. Clin Microbiol Rev 1999; 12: 518-553.
Field PR iet al. J Clin Microbiol. 2002; 40: 3526-3529.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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