The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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5 mL blood in lithium heparin tube.
Atomic absorption spectrophotometry.
There is significant variability in different countries and regions depending on dietary selenium.
Plasma: 0.75-1.35 µmol/L
Blood: 1.1-2.5 µmol/L
Detection of selenium deficiency in patients with dietary deficiency, especially patients on a non-supplemented synthetic amino acid diet (eg, phenylketonuria, total parenteral nutrition). Such diets are now usually supplemented with selenium.
Detection of selenium toxicity.
In humans significant selenium deficiency is manifest primarily as cardiomyopathy. This correlates poorly with plasma selenium levels and rarely occurs in selenium deficient patients on total parenteral nutrition.
Keshan disease, a cardiomyopathy in the low-selenium Keshan region of China, and Kashin-Beck disease, a destructive bone and joint disease in parts of China and Siberia, are related to selenium deficiency. The presence of iodine and selenium deficiency is associated with endemic cretinism in China and Africa.
Selenium toxicity is common in herbivores in seleniferous regions, but occurs in humans only after ingestion of selenium as a chemical, rather than from a high dietary intake.
Schrauzer GN. Adv Food Nutr Res. 2003; 47: 73-112.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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