The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Cardiac enzymes
5 mL blood in lithium heparin tube.
Not detected for conventional assays and POCTs. Assay and population dependent for high sensitivity troponin assays (99th %).
Diagnosis of Myocardial infarction.
The assays are specific for a cardiac isoform that occurs only in myocardium and, to a small extent, regenerating skeletal muscle.
The test is very specific and sensitive for myocardial damage.
Reference intervals are method dependent, and are also gender dependent for the high sensitivity troponin T assays.
The current generation high sensitivity troponin assays become positive within 2-3 hours of onset of chest pain and remain raised for 7-10 days. The conventional assays and POC tests for troponin become abnormal within 12 hours of commencement of pain.
Diagnostic thresholds are very method dependant. Ensure the diagnostic thresholds and timing of troponin tests are appropriate for the troponin assay in use.
Elevations of troponin are specific for myocardial damage, but not necessarily Myocardial infarction, which requires clinical features and a rise and or fall in troponin for diagnosis.
Lewandrowski K et al. Am J Clin Pathol. 2002; 118: 93-99.
Thygesen K et al. Eur Heart J 2012; 33: 2551-2567.
Thygesen K et al. J Am Coll Cardiol 2012; 60: 1581-1598.
Apple FS et al. Clin Chem 2012; 58: 1574-1581.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
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