The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: 5-aminolaevulinate urine, 5-aminolaevulinate - urine, delta - aminolaevulinate
Random urine; protect from light.
< 3.8 mmol/mol creatinine
< 35 mmol/L.
Diagnosis of acute neurological porphyrias during an acute episode. However, urine porphobilinogen is the preferred test, except for plumboporphyria.
Limited value in the diagnosis of lead poisoning as the test is less sensitive than blood lead and may be negative in organic lead poisoning (leaded petrol).
Increased levels are found during acute attacks of acute intermittent porphyria, hereditary coproporphyria, porphyria variegata and plumboporphyria.
In inorganic lead poisoning, porphobilinogen synthetase is inhibited, resulting in increased levels of 5-aminolaevulinate. However, the test does not reliably detect lead exposure in the distant past as, with time, lead is sequestered in bone. The test is also unreliable in patients with very recent exposure to organic lead eg, petrol sniffing.
Increased levels are found in patients with type 1 tyrosinaemia.
Thunell S et al. J Clin Chem Clin Biochem. 1987; 25: 5-14.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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