The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Keywords: Varicella zoster antibody, VZ antibody, Herpes zoster serology
5-10 mL blood in plain tube.
To determine susceptibility to infection with varicella zoster virus, particularly after exposure of an at-risk patient (eg, pregnancy, immunosuppression) to chicken pox (varicella) or shingles (herpes zoster).
Not necessary for the diagnosis of varicella or shingles, as clinical signs should make the diagnosis obvious. In atypical cases, the diagnosis is best made by viral antigen detection or by nucleic acid detection after amplification, depending on local availability.
In the rare case where the diagnosis is not clear from clinical findings and virus detection has not been successful a positive antibody result indicates previous varicella infection and likely immunity, although both false positives and false negatives occur.
A four-fold rise in titre over a 2-4 week period supports the diagnosis of acute varicella infection, but is less helpful in confirming a diagnosis of shingles.
Zoster immunoglobulin administration can result in detectable antibody levels for up to 10 weeks after the injection.
Arvin AM. Clin Microbiol Rev 1996; 9: 361-381.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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