von Willebrand factor multimer
4.5 mL blood added to 0.5 mL citrate or 5 mL blood in EDTA.
Crossed immunoelectrophoresis; SDS-agarose electrophoresis with autoradiography or enzyme-linked antibody staining.
Characterisation of patients with definite or highly probable von Willebrand's disease into subtypes (that is, 1, 2, 3 or platelet-type VWD).
May also be useful when assessing VWD defects of genetic significance and as a guide to management.
Multimers are not used as a screening test for von Willebrand's disease.
See von Willebrand disease testing, von Willebrand factor Ag, Ristocetin cofactor and Collagen binding assay.
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Sadler JE. Thromb Haemost 1994: 71; 520-525.