The main purpose of this Manual is to provide useful guidelines for the selection of pathology tests and to facilitate interpretation of results.
Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country.
A manual for the process of macroscopic dissection in Anatomical Pathology laboratories.
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Urine; 5 mL blood in a lithium heparin tube collected at intervals during the test.
Medical supervision must be provided during the test, which must be performed in a hospital setting.
The patient is allowed no oral or parenteral intake.
Plasma and urine specimens are collected hourly until osmolality reaches a plateau (< 30 mmol/kg increase over 1 h) or the patient becomes dehydrated (body weight decrease > 3 %). Desmopressin is then given and a further urine specimen is taken.
See Osmolality and Osmolality urine.
Osmolality urine > 2 x plasma Osmolality with < 9 % increase after DDAVP.
Diagnosis of central or nephrogenic Diabetes insipidus.
Complete central Diabetes insipidus: Osmolality urine remains lower than plasma Osmolality with > 50 % increase after DDAVP.
Partial central Diabetes insipidus: urine shows 10-50 % increase in Osmolality after DDAVP.
Nephrogenic Diabetes insipidus: Osmolality urine < 2 x plasma Osmolality with < 9 % increase after DDAVP.
Psychogenic polydipsia may resemble nephrogenic Diabetes insipidus, but the patient is usually hypo-osmolar and hyponatraemic.
Miller M et al. Ann Int Med 1970; 73: 721-729. C
Heetham T and Baylis PH. Paediatr Drugs 2002; 4(12): 785-796.
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The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.
Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.
The annual scientific meeting for the RCPA which covers the scientific disciplines of Anatomical, Chemical, Forensic, Genetic, General, Haematology, Immunopathology and Microbiology.
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